After peeking around the internet it looks like it is possible to interop between C# and Matlab. I am wondering if anyone has had success with it and what they did to do so. If possible somehow pulling it off without the use of COM. Thanks for your time.
Yes, quite possible. Though I ended up using the C interface and calling into that using a mixed-mode DLL (and getting C# to call into that... but that was because I was also interfacing with some other C code). It's quite straightforward. On computers where you want to run your program, you'll need to install Matlab Runtime MCRInstaller.exe.
edit: removed broken link
Beginning with the R2009a release of MATLAB, .NET objects can be accessed from MATLAB:
In older versions of MATLAB, it is possible to access .NET objects from MATLAB using CCW:
and the MATLAB engine from .NET:
You can also use the MATLAB Builder NE to wrap m-code into .NET assemblies.